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The initial and maintenance dosages of metformin hydrochloride in fixed combination with glyburide should be conservative and should be titrated carefully in such patients. Renal function should be assessed with initial dosage selection and with each dosage adjustment, particularly in geriatric patients, to aid in prevention of lactic acidosis.years of follow-up in patients glucophage xr buy online type 1 diabetes mellitus receiving intensive insulin treatment 3 or more insulin injections daily glucophage xr buy online dosage adjusted according to glucophage xr buys online of at least 4 daily blood glucose determinations, dietary intake, and anticipated exercise compared with that in patients receiving conventional insulin treatment 1 or 2 insulin injections daily, self-monitoring of blood or urine glucose values, education about diet and exercise However, the incidence of severe hypoglycemia, including multiple episodes in some patients, was 3 times higher in the intensive-treatment group than in the conventional-treatment group.

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