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Clinical data
PronunciationSee note at tretinoin
Trade namesAccutane (originator), others [1]
License dataUS   FDA: Isotretinoin
Pregnancy categoryAU: X (High risk) US: X (Contraindicated)
Routes of administrationBy mouth, topical
ATC codeD10AD04 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding99.9%
Elimination half-life10–20 hours
ExcretionRenal and fecal

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Isotretinoin is indicated for a severe, scarring form of acne, but is used off-label for other types of acne, as well.

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Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.rg/what-is-ulcerative-colitis U.

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These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD best chapstick when on accutane staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions.If severe acne returns, a second course of treatment may be started after you have stopped taking the drug for 2 months.

The manufacturer does not recommend long-term use of isotretinoin.


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