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Conjugated estrogens
Estrone sulfate, the primary active component in conjugated estrogens (constitutes about 50 to 70% of total content).
Equilin sulfate, the second most major active component in conjugated estrogens (constitutes about 20 to 30% of total content).
Combination of
Estrone sulfateEstrogen
Equilin sulfateEstrogen
17α-Dihydro-equilin sulfateEstrogen
Clinical data
Trade namesCenestin, Enjuvia, Congest, C.E.S., Premarin, Prempro (with MPA), Premphase (with MPA), others
AHFS/Drugs.comConsumer Drug Information
Pregnancy categoryX
Routes of administrationBy mouth, topical, vaginal, intravenous injection, intramuscular injection [1] [2]
Drug classEstrogen
ATC codeG03CA57 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityVariable [3]
Protein bindingHigh (to albumin and SHBG) [3] [1]
MetabolismLiver [3] [1]
Elimination half-lifeEstrone: 26.7 hours Estrone (BA): 14.8 hours Equilin: 11.4 hours [4]
ExcretionUrine [3]

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Premarin alternative name drug:
  • Cenestin 0.625 mg
  • Climopax 0.625 mg
  • Elredin 0.625 mg
  • Enjuvia 0.625 mg
  • Neradin 0.625 mg
  • Premphase 0.625 mg
  • Prempro 0.625 mg
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Premarin properties:

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