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Labetalol
Clinical data
Pronunciation/ l ə ˈ b ɛ t ə l ɔː l /
Trade namesNormodyne, Trandate, others
AHFS/Drugs.comMonograph
MedlinePlusa685034
Pregnancy categoryC One of few drugs used for PIH
Routes of administrationBy mouth, intravenous
ATC codeC07AG01 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability25%
Protein binding50%
MetabolismLiver pass metabolism
Elimination half-lifeTablet: 6-8 hours; IV: 5.5 hours
ExcretionExcreted in urine, not removed by hemodialysis

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Carteolol, Carvedilol, Labetalol , Nadolol, Penbutolol, Pindolol, Propranolol. Timolol, Sotalol; Cardioselective Beta Blockers: Acebutolol, Atenolol, Betaxolol.

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Labetalol has been shown to labetalol weight gain the placental labetalol weight gain in humans.During dosing with intravenous Labetalol HCl, the contribution of the postural component should be considered when positioning patients for treatment, and patients should not be allowed to move to an erect position unmonitored until their ability to do so is established. In a clinical pharmacologic study in severe hypertensives, an initial 0.

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Use of the drug has been associated with a reduction in the frequency and severity of anginal attacks, a decrease in nitrate dosage, and an increase in exercise tolerance. β-Blockers are recommended as the anti-ischemic drugs of choice in most patients with chronic stable angina; despite differences in cardioselectivity, intrinsic sympathomimetic activity, and other clinical factors, all β-blockers appear to be equally doe labetalol cause weight loss for this indication.Public Interest Research Group: "Blood doe labetalol cause weight loss medication recalled for 75th time in 8 months.

ngiotensin converting enzyme ACE inhibitors are high blood pressure drugs that widen or dilate the blood vessels to improve the amount of blood the heart pumps and to lower blood pressure.

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ACE inhibitors help the body doe labetalol cause weight gain less angiotensin, which helps the blood vessels relax and open up, which, in turn, lowers blood pressure.Following oral administration of a single 200-mg dose in healthy adults in one study, absolute bioavailability of the drug averaged 26 and 36% in the fasted and nonfasted state, respectively.

First-pass metabolism may also be reduced and bioavailability substantially increased in geriatric patients and in patients with hepatic dysfunction.

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Nylund L, Lunell NO, Lewander R et al.Following oral administration, labetalol undergoes extensive first-pass metabolism in the liver and/or GI mucosa. Labetalol and its metabolites are excreted in feces via biliary elimination and in urine.

Is magnesium sulfate compatible with labetalol?

Because of its usual lack of substantial changes in heart rate or cardiac output, IV labetalol may be particularly useful in severely hypertensive patients with ischemic heart disease.Effect of diuretics on fetal growth: a drug effect or confounding by indication?

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Therefore, these drugs should not be administered in the same infusion line. While taking beta-blockers, patients with a history of severe anaphylactic reactions to a variety of allergens may be more reactive to repeated challenge, either labetalol and weight gain, diagnostic, or therapeutic.Tenormin atenolol " ICN Pharmaceuticals Inc, Cost Mesa, CA. Eliasson K, Danielson M, Hylander B, Lindblad LE "Raynaud s labetalol and weight gain caused by beta-receptor blocking drugs.

Acta Med Scand 215 Holti G "A double-blind study of the peripheral vasoconstrictor effects of the beta-blocking drug penbutolol in patients with Raynaud s phenomenon.

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