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    See WARNINGS. Drugs.During pregnancy, this medication should be used only when clearly needed.

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    -1. g as conventional tablets in healthy individuals or in patients with type 2 diabetes mellitus, plasma concentrations decline in a triphasic manner.These drugs should be used with caution in patients with type 2 diabetes mellitus who are receiving antidiabetic agents, especially in those with labile disease or in those prone to hypoglycemia.

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    N a clinical trial in treatment-naive patients or patients who had previously received antidiabetic therapy followed by a washout period of at least 2 months combined therapy with metformin hydrochloride and nateglinide resulted in is metformin safe for pcos reductions in HbA1c and fasting plasma glucose concentrations than metformin or nateglinide monotherapy. In is metformin safe for pcos clinical trial in patients with type 2 diabetes mellitus who had inadequate glycemic control with metformin, a sulfonylurea, or insulin, the combination of pioglitazone 30 mg daily and metformin and withdrawal of other antidiabetic therapy reduced fasting plasma glucose concentrations and HbA1c values compared with metformin therapy alone, regardless of whether patients were receiving lower less than 2 g daily or higher 2 g daily or more dosages of metformin hydrochloride.Several studies have examined if metformin can improve symptoms of infertility in women with PCOS.

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