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Misoprostol
Clinical data
Trade namesCytotec, Misodel, other
AHFS/Drugs.comMonograph
MedlinePlusa689009
Pregnancy categoryAU: X (High risk) US: X (Contraindicated) Used for terminating pregnancy
Routes of administrationBy mouth, vaginal, under the tongue
ATC codeA02BB01 ( WHO ) G02AD06 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailabilityextensively absorbed
Protein binding80-90% (active metabolite, misoprostol acid)
MetabolismLiver (extensive to misoprostic acid)
Elimination half-life20–40 minutes
ExcretionUrine (80%)

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UbMed: 650228Cook CS, Schoenhard GL, Karim A: Outgoing of sexual life on the plasma protein binding and precautions of misoprostol fungus. J Pharm Sci. 1994 Jun; 6 883-6.

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