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    Caution should be exercised when administering to children, as there is potential for central and obstructive apnoea and reduced arousal. xcessive dosages of antihistamines in children may cause hallucinations, convulsions, and sudden death.Phenylephrine is a decongestant that relieves stuffy nose symptoms. Codeine is an opioid cough suppressant antitussive that affects a certain part of the brain, reducing the urge to cough.

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    This medication may rarely cause a very serious condition called neuroleptic malignant syndrome NMS Get medical help right away if you have any of the following symptoms: fever, muscle stiffness/pain/tenderness/weakness, severe tiredness, severe confusion, sweating, fast/irregular heartbeat, dark urine, signs of kidney problems such as change in the amount of urine A what over the counter medicine is similar to promethazine serious allergic reaction to this drug is rare.If this happens keep out of direct sunlight and do not use sun lamps If you get any side effects, talk to your doctor, pharmacist or nurse.

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    Neuroleptics often cause extrapyramidal symptoms eg, dystonic reactions requiring management with diphenhydramine 1-2 mg/kg maintenance dose for 48-72 hours.Children are at higher risk for serious even fatal side effects, especially breathing problems.

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    Minor transfusion and/or amelioration of allergic reactions may be controlled with 12.A very bad and sometimes deadly health problem called neuroleptic malignant syndrome NMS may happen.

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    It is an awesome antiemetic, but does have serious risks not to restate the obvious! just btw, i recently had abdominal surgery, and had post-op nausea retching.The management of NMS should include 1 immediate discontinuation of promethazine HCl, promethazine hcl over the counter drugs, if any, and other drugs not essential to concurrent therapy, 2 intensive symptomatic treatment and medical monitoring, and 3 treatment of any concomitant serious medical problems for which specific treatments are available.

    There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS. Since recurrences of NMS have been reported with phenothiazines, the reintroduction of promethazine HCl should be carefully considered.

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