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Clinical data
Trade namesUnisom, Vicks Formula 44 (in combination with Dextromethorphan), others
Pregnancy categoryAU: A US: B (No risk in non-human studies) A (Briggs)
Routes of administrationBy mouth
ATC codeR06AA09 ( WHO )
Legal status
Legal statusAU: S3 (Pharmacist only) US: OTC
Pharmacokinetic data
BioavailabilityOral: 24.7% [2] Intranasal: 70.8% [2]
MetabolismHepatic (CYP2D6, CYP1A2, CYP2C9) [1]
Elimination half-life10–12 hours [1]
ExcretionUrine (60%), feces (40%) [3]

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Active substancediphenhydramine
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