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Vardenafil
Clinical data
Trade namesLevitra, Staxyn, Vivanza
AHFS/Drugs.comMonograph
MedlinePlusa603035
License dataEU  EMA:  by INN
Pregnancy categoryAU: B3 US: B (No risk in non-human studies)
Routes of administrationOral
ATC codeG04BE09 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability15%
Protein binding95%
MetabolismHepatic (CYP3A4)
Elimination half-life4–5 hours
ExcretionBiliary

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CYP3A4 Inhibitors: The dosage of LEVITRA may require adjustment in patients receiving potent CYP3A4 levitra mechanisms of action such as ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, atazanavir, and clarithromycin as well as in other patients receiving moderate CYP3A4 inhibitors such as erythromycin see Drug Interactions 7.However, due to stock shortages and other unknown variables we cannot provide any guarantee.

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If you suffer from phenylketonuria a rare, hereditary disorder of the metabolism Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist Take a Vardenafil tablet about 25 to 60 minutes before sexual activity.White male, 104kg. No medical problem.

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There is no clinical levitra mechanism of action of any additive prolongation of the bleeding time when vardenafil is administered with aspirin. LEVITRA has not been administered to patients with bleeding disorders or significant active peptic ulceration.The inhibitory effect of vardenafil is more selective on PDE5 than for other known phosphodiesterases 15-fold levitra mechanism of action to PDE6, 130-fold relative to PDE1, 300-fold relative to PDE11, and 1, 00-fold relative to PDE.

8, 9, and 10 The pharmacokinetics of vardenafil are approximately dose proportional over the recommended dose range. Vardenafil is eliminated predominantly by hepatic metabolism, mainly by CYP3A4 and to a minor extent, CYP2C isoforms.

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Bacterial prostatitis can be cured with antibiotics; Erectile dysfunction ED, impotence is the failure to achieve or maintain an erection.You and your doctor should talk about LEVITRA when you start taking it and at regular checkups.

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Two patients on vardenafil in the trial reported episodes of transient cyanopsia objects appear blue Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15% Maximum observed levitra mechanism of action concentrations after a single 20 mg dose in healthy volunteers are usually reached between 30 minutes and 2 hours median 60 minutes after oral dosing in the fasted state.

Two food-effect studies were conducted which showed that high-fat meals caused a reduction in C The mean steady-state volume of distribution Vss for vardenafil is 208 L, indicating extensive tissue distribution.When vardenafil 20 mg film-coated tablets and alcohol mean maximum blood alcohol level of 73 mg/dl were taken together, vardenafil did not potentiate the effects of alcohol on blood pressure and heart rate and the pharmacokinetics of vardenafil were not altered.

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Vardenafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body.These events, which may be accompanied by vardenafil therapy with STAXYN.

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This is no longer supported Please levitra mechanism of action your version of Internet Explorer or use a different browser to use our website. If you are still having issues viewing this website please feel free to contact our support team Levitra and Viagra are both PDE5 inhibitors.In those patients who are stable on alpha-blocker therapy, LEVITRA should be initiated at a dose of 5 mg 2.

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