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Take the missed dose as soon as you remember.It undergoes N-demethylation to form N-desmethylsertraline, which is zoloft 75 less potent in its pharmacological activity than sertraline. In zoloft 75 to N-demethylation, sertraline metabolism involves N-hydroxylation, oxidative deamination, and finally, glucuronidation.

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Treatment of chronic pain needs to address the physical pathology that initiated the chronic pain, as well as the important social and psychologic sequelae of chronic symptoms.Elevations in aminotransferase concentrations usually occurred within the first 1-9 weeks of sertraline therapy and sertraline 75 mg rapidly reversible following discontinuance of the drug.


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